Virology News

 ”Single-virus genomics reveals hidden cosmopolitan and abundant viruses.

The authors apply single-virus genomics by fluorescence-activated sorting of single virus particles followed by whole-genome amplification to assess whether portions of marine viral communities are missed by current techniques including viral cultures. The results suggest that naked dsDNA viruses, in particular vSAG 37-F6, are putatively the most widely distributed, abundant, and likely active virus at the genus- and species-level taxa identified so far in the marine viriosphere.

Single-virus genomics reveals hidden cosmopolitan and abundant viruses. Martinez-Hernandez F, Fornas O, Lluesma Gomez M, Bolduc B, de la Cruz Peña MJ, Martínez JM, Anton J, Gasol JM, Rosselli R, Rodriguez-Valera F, Sullivan MB, Acinas SG, Martinez-Garcia M. Nat Commun. 2017 Jun 23;8:15892. doi: 10.1038/ncomms15892.

https://www.ncbi.nlm.nih.gov/pubmed/28643787


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”Reovirus infection trigger development of celiac disease”


Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. (http://science.sciencemag.org/content/356/6333/44) found that immune responses to two gut-infecting reoviruses take different paths in mice. Both reoviruses invoked protective immune responses, but for one reovirus, when infection happened in the presence of a dietary antigen (such as gluten or ovalbumin), tolerance to the dietary antigen was lost. This was because this strain prevented the formation of tolerogenic T cells. Instead, it promoted T helper 1 immunity to the dietary antigen through interferon regulatory factor 1 signaling. In a preliminary study, Celiac disease patients showed a tendency towards elevated levels of antibodies against reovirus.

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B. Science. 2017 Apr 7;356(6333):44-50. doi: 10.1126/science.aah5298.

https://www.ncbi.nlm.nih.gov/pubmed/28386004

 

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Mid-season real-time estimates of seasonal influenza vaccineeffectiveness in persons 65 years and older in register-based surveillance,Stockholm County, Sweden, and Finland, January 2017. Hergens MP, Baum U, Brytting M, Ikonen N, Haveri A, Wiman Å, Nohynek H, Örtqvist Å. Euro Surveill. 2017 Feb 23;22(8).

Real-time real-world analysis of seasonal influenza vaccineeffectiveness: method development and assessment of a population-based cohortin Stockholm County, Sweden, seasons 2011/12 to 2014/15. Leval A, Hergens MP, Persson K, Örtqvist Å. Euro Surveill. 2016 Oct 27;21(43).

Nucleic acid detection with CRISPR-Cas13a/C2c2. Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya R, Livny J, Regev A, Koonin EV, Hung DT, Sabeti PC, Collins JJ, Zhang F. Science. 2017 Apr 28;356(6336):438-442.