The authors have identified a long non-coding host RNA that is induced by infection and that promotes replication of both RNA (VSV) and DNA (HSV-1 and Vaccinia) viruses. Its mechanism of action, which does not involve the IFN system, is mediated through direct binding to the mitochondrial enzyme glutamic-oxaloacetic transaminase 2. This enzyme is translocated to the cytoplasm during VSV infection and binds to the non-coding RNA to alter cell metabolism in a manner that is suitable for viral replication. This mechanism may constitute a novel target for broad-spectrum antivirals.
An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism.
Wang P, Xu J, Wang Y, Cao X.
Science. 2017 Nov 24;358(6366):1051-1055. doi: 10.1126/science.aao0409.
Commentary: Viruses hijack a host lncRNA to replicate.
Kotzin JJ, Mowel WK, Henao-Mejia J.
Science. 2017 Nov 24;358(6366):993-994. doi: 10.1126/science.aar2300.