Virology News

     Acquired neurovirulence of enterovirus

Brown et al demonstrate that unlike older isolates of EV-D68, newer isolates are neurovirulent in vitro and i vivo and cause polio-like illness in animals. It is suggested that the enhanced neurotropism is at least partly caused by improved attachment to and entry into neural cells. This relates to recent outbreaks of acute flaccid paralysis in USA, Canada, Europe and Asia.

Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells.Brown DM, Hixon AM, Oldfield LM, Zhang Y, Novotny M, Wang W, Das SR, Shabman RS, Tyler KL, Scheuermann RH. MBio. 2018 Oct 16;9(5). pii: e01954-18. doi: 10.1128/mBio.01954-18. PMID: 30327438

https://mbio.asm.org/content/9/5/e01954-18.long

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Protocadherin-1 identified as key receptor for hantavirus

An international team headed by Kartik Chandran, one of the keynote speakers at this year Smögen Summer Symposium on Virology, recently reported on the identification of Protocadherin-1 as an essential receptor for viruses causing the highly fatal hantavirus pulmonary syndrome. By the use of genetic screens, in vitro and in vivo models, the entry and infection of pulmonary epithelial cells by new word hantaviruses, Sin Nombre virus and Andes virus, was shown to depend on the expression of Protocadherin-1, Accordingly, this finding may spur the development of prophylactic and therapeutic strategies against disease caused by these hantaviruses.  

Protocadherin-1 is essential for cell entry by New World hantaviruses. Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Román-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, Ng M, Mittler E, Pan J, Bharrhan S, Wec AZ, Lai JR, Sidhu SS, Tischler ND, Rey FA, Moffat J, Brummelkamp TR, Wang Z, Dye JM, Chandran K. Nature. 2018 Nov;563(7732):559-563. doi: 10.1038/s41586-018-0702-1. PMID: 30464266

https://www.nature.com/articles/s41586-018-0702-1