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A human natural antiviral ribonucleotide analogue activated by IFN-induced Viperin

Gizza et al. Nature. 2018 June; 558(7711):610-614

The Viperin protein is induced by IFN and known to elicit a broad range of antiviral activities. In a recent Nature issue Gizzi et al demonstrates that Viperin, via its SAM (S-adenosyl-L-methionine) domain, catalyzes conversion of CTP (cytidine triphosphate) to ddhCTP (3ʹ-deoxy-3,4ʹ-didehydro-CTP), which is a novel, and naturally occuring ribonucleotide analogue with antiviral activity against multiple types of Flaviviruses.